A door, hole, chute, or some other sort of mechanism that deploys constructs.
You disable a trap, lock, or other type of mechanism.
Some creatures have uncovered a hidden cache of drugs, and have now gone completely berserk. Whatever the origin of these drugs be it from black market dealers, smugglers, or hidden by adventurers themselves; The drugs must be destroyed to prevent further creatures from a similar fate.
Home for rodents that have dug through the earth.
A monstrosity of a goblin experiment gone wrong, these mindless beings are being used for something for a much worst purpose. And with every creation there is always a creator.
A goblin has been collecting opossums for some reason, it seems they have escaped and are running wild.
Either a group of monsters brought this chest or were attracted to the area because of it. However it happened, the monsters seem agitated protecting it or trying to open it. Who knows what riches lay within.